Sign conventions are more consistent across countries than you'd expect, with a handful of regional differences worth knowing.
Triangular signs usually mean caution, circular signs with a red border mean prohibition, and circular blue signs mean an instruction you're required to follow — a pattern that holds across much of Europe, Asia, and the Middle East. Distances and speed limits are posted in kilometers almost everywhere except the US and a handful of other countries.
Unmarked intersections are where local right-of-way habits matter most. In much of continental Europe, for instance, traffic approaching from the right often has priority by default unless a sign says otherwise.
When a sign doesn't register right away, slow down and watch what local drivers do at that same intersection — usually the fastest way to figure out an unfamiliar rule on the spot.